منابع مشابه
Acidic peptides of the lens.
The occurrence in lens extracts of acidic peptides, apparently derived from glutathione, was described in the first paper of this series (Waley, 1956). These compounds were isolated by electrophoresis; they migrated rapidly towards the anode at pH 4 (the 'fast-acid' fraction). A major constituent of this fraction (called lo4) was shown to have glutamic acid as the N-terminal amino acid of a tri...
متن کاملAcidic peptides of the lens. 7. The preparative enzymic synthesis of ophthalmic acid.
49(638)-764], from the National Institutes of Health, United States Public Health Service (No. A2650) and from the Foundation for the study of Diabetes and Related Metabolic Disorders. The authors would like to express their gratitude to Dr Ned Redgate of the Dept. of Physiology for the performance of the operative procedure involving the infusion of [35S]cystine into the third ventricle of the...
متن کاملAcidic peptides of the lens. 6. Metabolism of gamma-glutamyl peptides in subcellular fractions of rabbit liver.
The two tripeptides are similar in structure; they share some biological properties (Cliffe & Waley, 1958b), and compete in others (Cliffe & Waley, 1959a) and are synthesized by the same route in extracts of calf lens (Cliffe & Waley, 1958a). The comparison between ophthalmic acid and glutathione has now been extended by the choice of a tissue that not only contains enzymes that bring about the...
متن کاملGlial fibrillary acidic protein is localized in the lens epithelium
The epithelium of the mouse lens stains intensely with antisera to glial fibrillary acidic protein (GFAP). A protein co-migrating with GFAP and immunoreactive with antisera to GFAP can be demonstrated in lens epithelium protein extracts by immunoblots. GFAP has previously been considered unique to cells of neural origin, but this study demonstrates that ectodermally derived cells express GFAP o...
متن کاملAcidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns.
We have shown previously that FGF induces lens epithelial cells in explant culture to proliferate, migrate and differentiate into fibre cells in a progressive concentration-dependent manner. In situ, these processes occur in a distinct anterior-posterior pattern in clearly defined regions of the lens. Thus anterior-posterior differences in the bio-availability of FGF in the lens environment may...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1956
ISSN: 0306-3283
DOI: 10.1042/bj0640715